Synthesis of Tumor Necrosis Factor-α mRNA in Bronchoalveolar Lavage Cells from Human Immunodeficiency Virus-Infected Persons with Pneumocystis carinii Pneumonia
Identifieur interne : 002978 ( Main/Exploration ); précédent : 002977; suivant : 002979Synthesis of Tumor Necrosis Factor-α mRNA in Bronchoalveolar Lavage Cells from Human Immunodeficiency Virus-Infected Persons with Pneumocystis carinii Pneumonia
Auteurs : Neil Rayment [Royaume-Uni] ; Robert F. Miller [Royaume-Uni] ; Nabeel Ali [Royaume-Uni] ; Michael H. Binks [Royaume-Uni] ; David R. Katz [Royaume-Uni]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1996.
Abstract
Bronchoalveolar lavage fluid cells from a cohort of 34 human immunodeficiency virus-infected persons with established Pneumocystis carinii pneumonia were examined for expression of tumor necrosis factor-α (TNF-α) mRNA by fluorescence in situ hybridization with an antisense riboprobe. Video image analysis was used to develop a quantitative assay that evaluates relative single-cell levels of mRNA. The resulting data were analyzed as an antisense-to-sense ratio and examined for correlation between TNF-α mRNA expression and other measures of disease severity. Higher levels of TNF-α mRNA were seen in persons who had higher levels of arterial oxygen.
Url:
DOI: 10.1093/infdis/174.3.654
Affiliations:
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Binks</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Departments of Immunology and Sexually Transmitted Diseases, Division of Pathology and Infectious Diseases, University College London Medical School, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Katz, David R" sort="Katz, David R" uniqKey="Katz D" first="David R." last="Katz">David R. Katz</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Departments of Immunology and Sexually Transmitted Diseases, Division of Pathology and Infectious Diseases, University College London Medical School, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Reprints or correspondence: Dr. David R. Katz, Dept. of Immunology, Division of Pathology and Infectious Diseases, University College London Medical School, Windeyer Bldg., 46 Cleveland St., London W1P 6DB</wicri:regionArea><wicri:noRegion>London W1P 6DB</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1996-09">1996</date><biblScope unit="vol">174</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="654">654</biblScope><biblScope unit="page" to="659">659</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Bronchoalveolar lavage fluid cells from a cohort of 34 human immunodeficiency virus-infected persons with established Pneumocystis carinii pneumonia were examined for expression of tumor necrosis factor-α (TNF-α) mRNA by fluorescence in situ hybridization with an antisense riboprobe. Video image analysis was used to develop a quantitative assay that evaluates relative single-cell levels of mRNA. The resulting data were analyzed as an antisense-to-sense ratio and examined for correlation between TNF-α mRNA expression and other measures of disease severity. Higher levels of TNF-α mRNA were seen in persons who had higher levels of arterial oxygen.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Rayment, Neil" sort="Rayment, Neil" uniqKey="Rayment N" first="Neil" last="Rayment">Neil Rayment</name></region><name sortKey="Ali, Nabeel" sort="Ali, Nabeel" uniqKey="Ali N" first="Nabeel" last="Ali">Nabeel Ali</name><name sortKey="Binks, Michael H" sort="Binks, Michael H" uniqKey="Binks M" first="Michael H." last="Binks">Michael H. Binks</name><name sortKey="Katz, David R" sort="Katz, David R" uniqKey="Katz D" first="David R." last="Katz">David R. Katz</name><name sortKey="Katz, David R" sort="Katz, David R" uniqKey="Katz D" first="David R." last="Katz">David R. Katz</name><name sortKey="Miller, Robert F" sort="Miller, Robert F" uniqKey="Miller R" first="Robert F." last="Miller">Robert F. Miller</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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